The effect of carnosine or β-alanine supplementation on markers of glycaemic control and insulin resistance in human and animal studies: a protocol for a systematic review and meta-analysis

Matthews, Joseph J and Dolan, Eimear and Swinton, Paul A and Santos, Livia and Artioli, Guilherme G and Turner, Mark D and Elliott-Sale, Kirsty J and Sale, Craig (2020) The effect of carnosine or β-alanine supplementation on markers of glycaemic control and insulin resistance in human and animal studies: a protocol for a systematic review and meta-analysis. BMC Systematic Reviews, 9 (282). ISSN 2046-4053

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Abstract

Background: Diabetes is a major public health issue and there is a need to develop low-cost, novel interventions to prevent or reduce disease progression. Growing evidence shows that supplementation with carnosine, or its rate-limiting precursor β-alanine, can ameliorate aspects of the metabolic dysregulation that occurs in diabetes. There is, however, a need to develop a better understanding of the magnitude of effect and the factors associated with positive outcomes. The purpose of this systematic review and meta-analysis is to evaluate the effect of carnosine or β-alanine
supplementation on markers of glycaemic control and insulin resistance in humans and animals.

Methods: We will perform a systematic search for randomised and non-randomised controlled trials. Studies will be retrieved by searching electronic databases, clinical trial registers, author review, and cross-referencing. Primary outcomes include changes in (i) fasting glucose, (ii) glycated haemoglobin, and (iii) 2-h glucose following a glucose tolerance test. A set of additional outcomes includes other markers of glycaemic control and insulin resistance. Risk of bias (RoB) will be assessed using the Cochrane RoB 2.0 tool (human studies) and the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) RoB tool (animal studies). Confidence in the cumulative evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. All meta-analyses will be conducted within a Bayesian framework, providing a flexible modelling approach to account for uncertainty in model parameters and underlying structures within the data.

Discussion: By including all available human and animal data, we will provide the most comprehensive overview on the topic to date. The results will have implications for those working in prediabetes, diabetes, and metabolic health in general and may lead to the development of new treatment approaches.

Dissemination: Study results will be presented at a professional conference and published in a peer-reviewed journal.

Systematic review registration: CRD42020191588

Keywords: Diabetes, Prediabetes, Metabolic Health, Glucose, Therapeutics, Nutrition

Item Type: Article
Identification Number: https://doi.org/10.1186/s13643-020-01539-8
Date: 5 December 2020
Uncontrolled Keywords: Diabetes, Prediabetes, Metabolic health, Glucose, Therapeutics, Nutrition
Subjects: A300 Clinical Medicine
B100 Anatomy, Physiology and Pathology
B400 Nutrition
Divisions: Faculty of Health, Education and Life Sciences > Centre for Life and Sport Sciences (C-LASS)
Depositing User: Joseph Matthews
Date Deposited: 07 Dec 2020 11:31
Last Modified: 07 Dec 2020 11:31
URI: http://www.open-access.bcu.ac.uk/id/eprint/10470

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