The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers

Jahangiri, Leila and Pucci, Perla and Ishola, Tala and Trigg, Ricky M. and Williams, John A. and Pereira, Joao and Cavanagh, Megan L. and Turner, Suzanne D. and Gkoutos, Georgios V. and Tsaprouni, Loukia (2021) The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers. International Journal of Molecular Sciences, 22 (16). e8527. ISSN 1422-0067

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Abstract

MYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this transcription factor is implicated in metabolic reprogramming, cell death, and angiogenesis in cancers. In this review, we analyse MYC gene networks in solid cancers. We investigate the interaction of MYC with long non-coding RNAs (lncRNAs). Furthermore, we investigate the role of MYC regulatory networks in inducing changes to cellular processes, including autophagy and mitophagy. Finally, we review the interaction and mutual regulation between MYC and lncRNAs, and autophagic processes and analyse these networks as unexplored areas of targeting and manipulation for therapeutic gain in MYC-driven malignancies.

Item Type: Article
Additional Information: ** From MDPI via Jisc Publications Router ** History: accepted 05-08-2021; pub-electronic 08-08-2021. ** Licence for this article: https://creativecommons.org/licenses/by/4.0/
Identification Number: https://doi.org/10.3390/ijms22168527
Dates:
DateEvent
5 August 2021Accepted
8 August 2021Published
Uncontrolled Keywords: MYC, gene regulatory networks (GRNs), autophagy, lncRNAs
Subjects: CAH01 - medicine and dentistry > CAH01-01 - medicine and dentistry > CAH01-01-01 - medical sciences (non-specific)
Divisions: Faculty of Health, Education and Life Sciences > Centre for Life and Sport Sciences (C-LASS)
SWORD Depositor: JISC PubRouter
Depositing User: JISC PubRouter
Date Deposited: 18 Aug 2021 10:54
Last Modified: 12 Jan 2022 11:13
URI: http://www.open-access.bcu.ac.uk/id/eprint/12027

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