Dynamically expressed single ELAV/Hu orthologue elavl2 of bees is required for learning and memory

Ustaoglu, Pinar and Gill, Jatinder Kaur and Doubovetzky, Nicolas and Haussmann, Irmgard U. and Dix, Thomas C and Arnold, Roland and Devaud, Jean-Marc and Soller, Matthias (2021) Dynamically expressed single ELAV/Hu orthologue elavl2 of bees is required for learning and memory. Communications Biology, 4 (1). p. 1234. ISSN 2399-3642

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Abstract

Changes in gene expression are a hallmark of learning and memory consolidation. Little is known about how alternative mRNA processing, particularly abundant in neuron-specific genes, contributes to these processes. Prototype RNA binding proteins of the neuronally expressed ELAV/Hu family are candidates for roles in learning and memory, but their capacity to cross-regulate and take over each other's functions complicate substantiation of such links. Honey bees Apis mellifera have only one elav/Hu family gene elavl2, that has functionally diversified by increasing alternative splicing including an evolutionary conserved microexon. RNAi knockdown demonstrates that ELAVL2 is required for learning and memory in bees. ELAVL2 is dynamically expressed with altered alternative splicing and subcellular localization in mushroom bodies, but not in other brain regions. Expression and alternative splicing of elavl2 change during memory consolidation illustrating an alternative mRNA processing program as part of a local gene expression response underlying memory consolidation.

Item Type: Article
Additional Information: ** From Europe PMC via Jisc Publications Router ** History: ppub 01-10-2021; epub 28-10-2021. ** Licence for this article: cc by
Identification Number: https://doi.org/10.1038/s42003-021-02763-1
Dates:
DateEvent
9 October 2021Accepted
28 October 2021Published Online
Uncontrolled Keywords: Animals, Bees, RNA-Binding Proteins, Insect Proteins, Learning, Memory, Gene Expression, Alternative Splicing
Subjects: CAH03 - biological and sport sciences > CAH03-01 - biosciences > CAH03-01-02 - biology (non-specific)
CAH03 - biological and sport sciences > CAH03-01 - biosciences > CAH03-01-07 - genetics
Divisions: Faculty of Health, Education and Life Sciences > Centre for Life and Sport Sciences (C-LASS)
SWORD Depositor: JISC PubRouter
Depositing User: JISC PubRouter
Date Deposited: 17 Jan 2022 14:13
Last Modified: 17 Jan 2022 14:13
URI: http://www.open-access.bcu.ac.uk/id/eprint/12579

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