Pregabalin Assay in a Patient with Widespread Neuropathic Pain and Late Onset Gluten Intolerance

Hanu-Cernat, D.E. and Phipps, A.N. and Raphael, J.H. (2011) Pregabalin Assay in a Patient with Widespread Neuropathic Pain and Late Onset Gluten Intolerance. Pain Medicine, 12 (8). pp. 1262-1266. ISSN 15262375 (ISSN)

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Abstract

Objective. The aim of this study was to determine the pharmacokinetics of pregabalin in a patient with malabsorption secondary to celiac disease and compare the findings with the data available from pre-existing studies in healthy volunteer controls. Methods. A 39-year-old man consented to a 24-hour pregabalin assay with sequential pre and post-dose blood sampling. Results. The blood levels measured in this subject were no different to healthy male volunteers enrolled in previous studies. Conclusion. Although the results obtained are encouraging, the wide spectrum of effects and interactions of various drugs in malabsorption would suggest that therapy of any kind should be considered at individual level and monitored with blood assays. Wiley Periodicals, Inc.

Item Type: Article
Uncontrolled Keywords: Celiac Disease, Neuropathic Pain, Pharmacokinetics, Pregabalin, buprenorphine, codeine, gabapentin, glucose, immunoglobulin A, immunoglobulin G, opiate, paracetamol, pregabalin, tramadol, add on therapy, adult, article, blood sampling, bone densitometry, case report, celiac disease, clinical feature, drowsiness, drug absorption, drug blood level, drug determination, drug efficacy, drug half life, drug mechanism, dysesthesia, gluten free diet, glycemic control, human, human tissue, male, neuropathic pain, spinal pain, thoracic spinal cord, treatment response, weight reduction, Adult, Analgesics, Animals, Celiac Disease, gamma-Aminobutyric Acid, Humans, Male, Neuralgia
Subjects: A300 Clinical Medicine
Divisions: UoA Collections > UoA 03: Allied Health Professions, Dentistry, Nursing & Pharmacy
Depositing User: Hussen Farooq
Date Deposited: 25 Feb 2017 14:43
Last Modified: 25 Feb 2017 14:43
URI: http://www.open-access.bcu.ac.uk/id/eprint/2110

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