Topical negative pressure for treating chronic wounds

Ubbink, D.T. and Westerbos, S.J. and Evans, D. and Land, L. and Vermeulen, H. (2008) Topical negative pressure for treating chronic wounds. Cochrane Database of Systematic Reviews (3). ISSN 1469493X (ISSN)

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Background: Chronic wounds mainly affect the elderly and those with multiple health problems. Despite the use of modern dressings, some of these wounds take a long time to heal, fail to heal, or recur, causing significant pain and discomfort to the person and cost to health services. Topical negative pressure (TNP) is used to promote healing of surgical wounds by using suction to drain excess fluid from wounds. Objectives: To assess the effects of TNP on chronic wound healing. Search strategy: For this second update of this review we searched the Cochrane Wounds Group Specialised Register (December 2007), The Cochrane Central Register of Controlled Trials (CENTRAL) - The Cochrane Library Issue 4, 2007, Ovid MEDLINE - 1950 to November Week 2 2007, Ovid EMBASE - 1982 to 2007 Week 50 and Ovid CINAHL - 1980 to December Week 1 2007. In addition, we contacted authors, companies, manufacturers, and distributors to identify relevant trials and information. Selection criteria: All randomised controlled trials which evaluated the effects of TNP on people with chronic wounds. Data collection and analysis: Selection of the trials, quality assessment, data abstraction, and data synthesis were done by two authors independently. Disagreements were solved by discussion. Main results: Two trials were included in the original review. A further five trials were included in this second update resulting in a total of seven trials involving 205 participants. The seven trials compared TNP with five different comparator treatments. Four trials compared TNP with gauze soaked in either 0.9% saline or Ringer's solution. The other three trials compared TNP with hydrocolloid gel plus gauze, a treatment package comprising papain-urea topical treatment, and cadexomer iodine or hydrocolloid, hydrogels, alginate and foam. These data do not show that TNP significantly increases the healing rate of chronic wounds compared with comparators. Data on secondary outcomes such as infection rate, quality of life, oedema, hospitalisation and bacterial load were not reported. Authors' conclusions: Trials comparing TNP with alternative treatments for chronic wounds have methodological flaws and data do demonstrate a beneficial effect of TNP on wound healing however more, better quality research is needed. Copyright © 2008 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

Item Type: Article
Identification Number:
Uncontrolled Keywords: *Wound healing, Bandages, Chronic disease, Humans, Randomized controlled trials as topic, Suction [*methods], alginic acid, cadexomer iodine, papain, urea, chronic wound, CINAHL, Cochrane Library, data synthesis, foam, gauze dressing, hospitalization, human, hydrocolloid dressing, hydrogel, infection rate, MEDLINE, negative pressure ventilation, outcome assessment, quality control, quality of life, review, surgical wound, survival rate, systematic review, therapy effect, vacuum assisted closure, wound care, wound complication, wound dressing, wound healing
Subjects: CAH02 - subjects allied to medicine > CAH02-04 - nursing and midwifery > CAH02-04-01 - nursing (non-specific)
Divisions: Faculty of Health, Education and Life Sciences > Centre for Social Care, Health and Related Research (C-SHARR)
Depositing User: Yasser Nawaz
Date Deposited: 25 Feb 2017 15:21
Last Modified: 03 Mar 2022 17:16

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