Acute Ethanol Inhibition of γ Oscillations Is Mediated by Akt and GSK3β

Wang, Jiangang and Zhao, JingXi and Liu, ZhiHua and Guo, FangLi and Wang, Yali and Wang, Xiaofang and Zhang, Ruiling and Vreugdenhil, Martin and Lu, Chengbiao (2016) Acute Ethanol Inhibition of γ Oscillations Is Mediated by Akt and GSK3β. Frontiers in Cellular Neuroscience, 10. pp. 1-12. ISSN 1662-5102

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Abstract

Hippocampal network oscillations at gamma band frequency (γ, 30–80 Hz) are closely associated with higher brain functions such as learning and memory. Acute ethanol exposure at intoxicating concentrations (≥50 mM) impairs cognitive function. This study aimed to determine the effects and the mechanisms of acute ethanol exposure on γ oscillations in an in vitro model. Ethanol (25–100 mM) suppressed kainate-induced γ oscillations in CA3 area of the rat hippocampal slices, in a concentration-dependent, reversible manner. The ethanol-induced suppression was reduced by the D1R antagonist SCH23390 or the PKA inhibitor H89, was prevented by the Akt inhibitor triciribine or the GSk3β inhibitor SB415286, was enhanced by the NMDA receptor antagonist D-AP5, but was not affected by the MAPK inhibitor U0126 or PI3K inhibitor wortmanin. Our results indicate that the intracellular kinases Akt and GSk3β play a critical role in the ethanol-induced suppression of γ oscillations and reveal new cellular pathways involved in the ethanol-induced cognitive impairment.

Item Type: Article
Identification Number: https://doi.org/10.3389/fncel.2016.00189
Date: 17 August 2016
Subjects: B100 Anatomy, Physiology and Pathology
Divisions: Faculty of Health, Education and Life Sciences > Centre for Social Care, Health and Related Research (C-SHARR) > Health Sciences
Faculty of Health, Education and Life Sciences > School of Health Sciences
Depositing User: Users 18 not found.
Date Deposited: 03 Jan 2017 12:23
Last Modified: 30 Sep 2020 14:18
URI: http://www.open-access.bcu.ac.uk/id/eprint/3652

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