Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

Cho, Yoon Shin and Chen, Chien-Hsiun and Hu, Cheng and Long, Jirong and Ong, Rick Twee Hee and Sim, Xueling and Takeuchi, Fumihiko and Wu, Ying and Go, Min Jin and Yamauchi, Toshimasa and Chang, Yi-Cheng and Kwak, Soo Heon and Ma, Ronald C W and Yamamoto, Ken and Adair, Linda S and Aung, Tin and Cai, Qiuyin and Chang, Li-Ching and Chen, Yuan-Tsong and Gao, Yutang and Hu, Frank B and Kim, Hyung-Lae and Kim, Sangsoo and Kim, Young Jin and Lee, Jeannette Jen-Mai and Lee, Nanette R and Li, Yun and Liu, Jian Jun and Lu, Wei and Nakamura, Jiro and Nakashima, Eitaro and Ng, Daniel Peng-Keat and Tay, Wan Ting and Tsai, Fuu-Jen and Wong, Tien Yin and Yokota, Mitsuhiro and Zheng, Wei and Zhang, Rong and Wang, Congrong and So, Wing Yee and Ohnaka, Keizo and Ikegami, Hiroshi and Hara, Kazuo and Cho, Young Min and Cho, Nam H and Chang, Tien-Jyun and Bao, Yuqian and Hedman, Åsa K and Morris, Andrew P and McCarthy, Mark I and Takayanagi, Ryoichi and Park, Kyong Soo and Jia, Weiping and Chuang, Lee-Ming and Chan, Juliana C N and Maeda, Shiro and Kadowaki, Takashi and Lee, Jong-Young and Wu, Jer-Yuarn and Teo, Yik Ying and Tai, E Shyong and Shu, Xiao Ou and Mohlke, Karen L and Kato, Norihiro and Han, Bok-Ghee and Seielstad, Mark and Tsaprouni, Loukia (2011) Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nature genetics, 44 (1). pp. 67-72. ISSN 1546-1718

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Abstract

We conducted a three-stage genetic study to identify susceptibility loci for type 2 diabetes (T2D) in east Asian populations. We followed our stage 1 meta-analysis of eight T2D genome-wide association studies (6,952 cases with T2D and 11,865 controls) with a stage 2 in silico replication analysis (5,843 cases and 4,574 controls) and a stage 3 de novo replication analysis (12,284 cases and 13,172 controls). The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3. GLIS3, which is involved in pancreatic beta cell development and insulin gene expression, is known for its association with fasting glucose levels. The evidence of an association with T2D for PEPD and HNF4A has been shown in previous studies. KCNK16 may regulate glucose-dependent insulin secretion in the pancreas. These findings, derived from an east Asian population, provide new perspectives on the etiology of T2D.

Item Type: Article
Subjects: C400 Genetics
C700 Molecular Biology, Biophysics and Biochemistry
C900 Others in Biological Sciences
Divisions: UoA Collections > UoA 03: Allied Health Professions, Dentistry, Nursing & Pharmacy
Faculty of Health, Education and Life Sciences > School of Health Sciences
Depositing User: Loukia Tsaprouni
Date Deposited: 17 Jul 2017 08:46
Last Modified: 17 Jul 2017 08:46
URI: http://www.open-access.bcu.ac.uk/id/eprint/4791

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