Cortical and Subcortical Gray Matter Volume in Youths With Conduct Problems
Rogers, Jack C. and De Brito, Stéphane A. (2015) Cortical and Subcortical Gray Matter Volume in Youths With Conduct Problems. JAMA Psychiatry, 73 (1). p. 64. ISSN 2168-622X
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Abstract
Importance: A large number of structural neuroimaging studies have used voxel-based morphometry (VBM) to identify gray matter abnormalities in youths with conduct problems (CP), but the findings have been disparate and few have been replicated.
Objective: To conduct a meta-analysis of published whole-brain structural neuroimaging studies on CP that used VBM methods to facilitate replication and aid further analyses by researchers.
Data Sources: The PubMed, ScienceDirect, Scopus and Web-of-Science databases were searched identifying VBM studies published between 2007 and March 2015. Manual searches were conducted using title and citation information. Authors were contacted soliciting additional data.
Study Selection: A literature search revealed 28 studies, with 13 eligible for inclusion (394 youths with CP and 350 typically-developing [TD] youths).
Data Extraction and Synthesis: Anisotropic effect-size Signed Differential Mapping was used for voxel-based meta-analyses. Statistical parametric maps comparing gray matter differences between youths with CP and TD youths were available for 11 of the studies, with peak coordinates available for the remaining studies.
Main Outcome(s) and Measure(s): Regional gray matter volume (GMV) differences in youths with CP compared to TD youths.
Results: Youths with CP had decreased GMV in left amygdala (SDM-estimate=-0.218;p=0.00002) (extending into anterior insula), right insula (SDM-estimate=-0.174;p=0.0004) (extending ventro-laterally into prefrontal cortex and inferiorly into superior temporal gyrus), left medial superior frontal gyrus (SDM-estimate=-0.163;p=0.001) (extending into right anterior cingulate cortex) and left fusiform gyrus (SDM-estimate=-0.146;p=0.003). Sub-group meta-analysis assessing age-of-onset effects identified reduced GMV in the left amygdala (SDM-estimate=-0.232;p=0.0002) extending into anterior insula. Meta-regression analyses revealed that greater scores on measures of callous-unemotional traits were associated with a lower reduction in GMV in left putamen (SDM-estimate=-0.911;p=0.00006). The proportion of males and females in the sample related to decreased GMV in left amygdala (SDM-estimate=-0.31;p=0.000003) and increased GMV in right inferior temporal cortex (SDM-estimate=0.755;p=0.00001). Whilst there was no association with co-morbid ADHD or IQ, age-range did contribute to gray matter differences in left amygdala.
Conclusions and Relevance: We identified gray matter reductions within the insula, amygdala, frontal and temporal regions as the most consistent in CP as well as inconsistencies in sample characteristics across studies that should be addressed in future research.
| Item Type: | Article | ||||||
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| Identification Number: | https://doi.org/10.1001/jamapsychiatry.2015.2423 | ||||||
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| Subjects: | CAH04 - psychology > CAH04-01 - psychology > CAH04-01-01 - psychology (non-specific) | ||||||
| Divisions: | Faculty of Business, Law and Social Sciences > School of Social Sciences > Dept. Psychology | ||||||
| Depositing User: | Silvio Aldrovandi | ||||||
| Date Deposited: | 03 Apr 2018 16:27 | ||||||
| Last Modified: | 03 Mar 2022 15:42 | ||||||
| URI: | https://www.open-access.bcu.ac.uk/id/eprint/5797 |
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