Effects of short-term temperature change in the innocuous range on histaminergic and non-histaminergic acute itch

Lewis, Z and George, D and Cowdell, Fiona and Holle, H (2018) Effects of short-term temperature change in the innocuous range on histaminergic and non-histaminergic acute itch. Acta Dermato-Venereologica. (In Press)

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Abstract

While temperatures in the noxious range are well-known to inhibit acute itch, the impact of temperature in the innocuous temperature range is less well understood. We investigated the effect of alternating short-term temperature changes in the innocuous range on histamine and cowhage-induced acute itch, taking into account individual differences in baseline skin temperature and sensory thresholds. Results indicate that cooling the skin to the cold threshold causes a temporary increase in the intensity of histamine-induced itch, in line with previous findings. Skin warming increased cowhage-induced itch intensity. Potential mechanisms of this interaction between thermosensation and pruritoception could involve cold-sensitive channels such as TRPM8, TREK-1 or TRPC5 in the case of histamine. The rapid modulation of cowhage induced itch - but not histamine-induced itch - by transient skin warming could be related to the lower temperature threshold of pruriceptive polymodal C-fibres (cowhage) as compared to the higher temperature threshold of the mechanoinsensitive C-Fibres conveying histaminergic itch.

Item Type: Article
Uncontrolled Keywords: Skin temperature, Histamine, Sensory Thresholds, Pruritus
Subjects: B700 Nursing
Divisions: UoA Collections > REF2021 UoA 03: Allied Health Professions, Dentistry, Nursing & Pharmacy
Depositing User: Fiona Cowdell
Date Deposited: 22 Oct 2018 08:52
Last Modified: 22 Oct 2018 08:52
URI: http://www.open-access.bcu.ac.uk/id/eprint/6492

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