Effects of short-term temperature change in the innocuous range on histaminergic and non-histaminergic acute itch
Lewis, Z and George, D and Cowdell, Fiona and Holle, H (2019) Effects of short-term temperature change in the innocuous range on histaminergic and non-histaminergic acute itch. Acta Dermato-Venereologica, 99. pp. 188-195.
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Abstract
While temperatures in the noxious range are well-known to inhibit acute itch, the impact of temperature in the innocuous temperature range is less well understood. We investigated the effect of alternating short-term temperature changes in the innocuous range on histamine and cowhage-induced acute itch, taking into account individual differences in baseline skin temperature and sensory thresholds. Results indicate that cooling the skin to the cold threshold causes a temporary increase in the intensity of histamine-induced itch, in line with previous findings. Skin warming increased cowhage-induced itch intensity. Potential mechanisms of this interaction between thermosensation and pruritoception could involve cold-sensitive channels such as TRPM8, TREK-1 or TRPC5 in the case of histamine. The rapid modulation of cowhage induced itch - but not histamine-induced itch - by transient skin warming could be related to the lower temperature threshold of pruriceptive polymodal C-fibres (cowhage) as compared to the higher temperature threshold of the mechanoinsensitive C-Fibres conveying histaminergic itch.
| Item Type: | Article | ||||||
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| Identification Number: | https://doi.org/10.2340/00015555-3077 | ||||||
| Dates: |
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| Uncontrolled Keywords: | Skin temperature, Histamine, Sensory Thresholds, Pruritus | ||||||
| Subjects: | CAH02 - subjects allied to medicine > CAH02-04 - nursing and midwifery > CAH02-04-01 - nursing (non-specific) | ||||||
| Divisions: | Faculty of Health, Education and Life Sciences > School of Nursing and Midwifery | ||||||
| Depositing User: | Fiona Cowdell | ||||||
| Date Deposited: | 22 Oct 2018 08:52 | ||||||
| Last Modified: | 03 Mar 2022 15:37 | ||||||
| URI: | https://www.open-access.bcu.ac.uk/id/eprint/6492 |
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