Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations.

Powell, A.D. (2018) Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations. Nature Neuroscience. (In Press)

[img] Text
Chang_NN_Manuscript.pdf - Accepted Version
Restricted to Repository staff only until 15 April 2019.

Download (1MB) | Request a copy

Abstract

The mechanisms of seizure emergence, and the role of brief interictal epileptiform discharges (IEDs) in seizure generation are two of the most important unresolved issues in modern epilepsy research. Our study shows that the transition to seizure is not a sudden phenomenon,but a slow process characterized by the progressive loss of neuronal network resilience. From a dynamical perspective, the slow transition is governed by the principles of critical slowing, a robust natural phenomenon observable in systems characterized by transitions between dynamical regimes. In epilepsy, this process is modulated by the synchronous synaptic input from IEDs. IEDs are external perturbations that produce phasic changes in the slow transition process and exert opposing effects on the dynamics of a seizure-generating network, causing either anti-seizure or pro-seizure effects. We show that the multifaceted nature of IEDs is defined by the dynamical state of the network at the moment of the discharge occurrence.

Item Type: Article
Subjects: A100 Pre-clinical Medicine
A300 Clinical Medicine
B100 Anatomy, Physiology and Pathology
B200 Pharmacology, Toxicology and Pharmacy
C700 Molecular Biology, Biophysics and Biochemistry
Divisions: Faculty of Health, Education and Life Sciences > School of Health Sciences
Depositing User: Andrew Powell
Date Deposited: 05 Nov 2018 09:25
Last Modified: 05 Nov 2018 09:25
URI: http://www.open-access.bcu.ac.uk/id/eprint/6526

Actions (login required)

View Item View Item

Research

In this section...