The modulation of acute methamphetamine on the neuronal network oscillations in rat hippocampal CA3 area.

li, Yanan and Xie, Xin'e and Xing, Hang and Yuan, Xiang and Wang, Yuan and Jin, Yikai and Wang, Jiangang and Vreugdenhil, Martin and Zhoa, Ying and Zhang, Ruiling and Lu, Chengbiao (2019) The modulation of acute methamphetamine on the neuronal network oscillations in rat hippocampal CA3 area. Frontiers in Cellular Neurosceince, 13 (277).

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Abstract

Gamma frequency oscillations (γ, 30–100 Hz) have been suggested to underlie various cognitive and motor functions. The psychotomimetic drug methamphetamine (MA) enhances brain γ oscillations associated with changes in psychomotor state. Little is known about the cellular mechanisms of MA modulation on γ oscillations. We explored the effects of multiple intracellular kinases on MA modulation of γ induced by kainate in area CA3 of rat ventral hippocampal slices. We found that dopamine receptor type 1 and 2 (DR1 and DR2) antagonists, the serine/threonine kinase PKB/Akt inhibitor and N-methyl-D-aspartate receptor (NMDAR) antagonists prevented the enhancing effect of MA on γ oscillations, whereas none of them affected baseline γ strength. Protein kinase A, phosphoinositide 3-kinase and extracellular signal-related kinases inhibitors had no effect on MA. We propose that the DR1/DR2-Akt-NMDAR pathway plays a critical role for the MA enhancement of γ oscillations. Our study provides an new insight into the mechanisms of acute MA on MA-induced psychosis.

Item Type: Article
Identification Number: https://doi.org/10.3389/fncel.2019.00277
Date: 21 June 2019
Subjects: A100 Pre-clinical Medicine
B200 Pharmacology, Toxicology and Pharmacy
Divisions: REF UoA Output Collections > REF2021 UoA 04: Psychology, Psychiatry and Neuroscience
Faculty of Business, Law and Social Sciences > School of Social Sciences > Dept. Psychology
Depositing User: Martin Vreugdenhil
Date Deposited: 19 Aug 2019 15:12
Last Modified: 19 Aug 2019 15:12
URI: http://www.open-access.bcu.ac.uk/id/eprint/7878

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