A meta-analysis of sex differences in human brain structure

Ruigrok, structureAmber N.V. and Salimi-Khorshidi, Gholamreza and Lai, Meng-Chuan and Baron-Cohen, Simon and Lombardo, Michael V. and Tait, Roger and Suckling, John (2013) A meta-analysis of sex differences in human brain structure. Neuroscience and Biobehavioral Reviews.

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tThe prevalence, age of onset, and symptomatology of many neuropsychiatric conditions differ betweenmales and females. To understand the causes and consequences of sex differences it is important to estab-lish where they occur in the human brain. We report the first meta-analysis of typical sex differences onglobal brain volume, a descriptive account of the breakdown of studies of each compartmental volumeby six age categories, and whole-brain voxel-wise meta-analyses on brain volume and density. Gaussian-process regression coordinate-based meta-analysis was used to examine sex differences in voxel-basedregional volume and density. On average, males have larger total brain volumes than females. Exami-nation of the breakdown of studies providing total volumes by age categories indicated a bias towardsthe 18–59 year-old category. Regional sex differences in volume and tissue density include the amyg-dala, hippocampus and insula, areas known to be implicated in sex-biased neuropsychiatric conditions.Together, these results suggest candidate regions for investigating the asymmetric effect that sex has onthe developing brain, and for understanding sex-biased neurological and psychiatric conditions.

Item Type: Article
17 December 2013Accepted
Subjects: CAH11 - computing > CAH11-01 - computing > CAH11-01-01 - computer science
Divisions: Faculty of Computing, Engineering and the Built Environment > School of Computing and Digital Technology
Depositing User: Roger Tait
Date Deposited: 24 Aug 2019 08:10
Last Modified: 22 Mar 2023 12:02
URI: https://www.open-access.bcu.ac.uk/id/eprint/7895

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