Cerebrospinal fluid opening pressure: the effect of body mass index and body composition

Wakerley, Ben and Warner, Richard and Cole, Matthew and Stone, Keeron (2019) Cerebrospinal fluid opening pressure: the effect of body mass index and body composition. Clinical Neurology and Neurosurgery.

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Abstract

Objectives
Idiopathic intracranial hypertension (IIH) is strongly related to obesity. The relationship between intracranial pressure, body mass index (BMI), percentage body fat and distribution of body fat in non-IIH patients remains less clear. The aim of this study was to examine the relationship between intracranial pressure and body type in non-IIH patients.
Patients and Methods
Lumbar puncture manometry was used to measure cerebrospinal fluid opening pressure (CSFOP). BMI, in addition to neck, waist and hip circumferences were calculated. Air displacement plethysmography (BODPOD) was used to assess body composition.
Results
Data was collected from 100 subjects. 11 subjects with conditions known to cause raised intracranial pressure were excluded from analysis. According to Pearson correlation factors displaying a significant relationship with CSFOP included: BMI (R = 0.635, p < 0.0001); waist circumference (R = 0.498, p < 0.0001), hip circumference (R = 0.513, p < 0.0001) and percentage body fat (R = 0.435, p < 0.001). Multivariate analysis indicated that BMI was the only independent factor which predicted CSFOP. Sub-analysis according to gender indicated that BMI was predictive in females and percentage body fat was predictive in males. We did not identify any differences in BMI, percentage body fat or distribution of body fat in 7 IIH patients and 7 weight-matched non-IIH patients.
Conclusion
BMI and %body fat both positively correlated with CSFOP, but BMI was more predictive in women and %body fat was more predictive in men. We did not find a relationship between distribution of body fat and CSFOP.

Item Type: Article
Date: 13 November 2019
Subjects: A300 Clinical Medicine
B400 Nutrition
Divisions: Faculty of Health, Education and Life Sciences > School of Health Sciences
Depositing User: Matthew Cole
Date Deposited: 19 Nov 2019 13:53
Last Modified: 27 Jan 2020 11:20
URI: http://www.open-access.bcu.ac.uk/id/eprint/8431

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