Paediatric Burkitt lymphoma patient-derived xenografts capture disease characteristics over time and are a model for therapy

Forde, Sorcha and Matthews, Jamie D and Jahangiri, Leila and Lee, Liam and Prokoph, Nina and Malcolm, Tim and Giger, Olivier and Bell, Natalie and Blair, Helen and O’Marcaigh, Aengus and Smith, Owen and Kenner, Lukas and Bomken, Simon and Burke, Gladstone A. A. and Turner, Suzanne D (2020) Paediatric Burkitt lymphoma patient-derived xenografts capture disease characteristics over time and are a model for therapy. British Journal of Haematology. ISSN 0007-1048

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Abstract

Burkitt lymphoma (BL) accounts for almost two-thirds of all B-cell non- Hodgkin lymphoma (B-NHL) in children and adolescents and is charac- terised by a MYC translocation and rapid cell turnover. Intensive chemotherapeutic regimens have been developed in recent decades, includ- ing the lymphomes malins B (LMB) protocol, which have resulted in a sur- vival rate in excess of 90%. Recent clinical trials have focused on immunochemotherapy, with the addition of rituximab to chemotherapeutic backbones, showing encouraging results. Despite these advances, relapse and refractory disease occurs in up to 10% of patients and salvage options for these carry a dismal prognosis. Efforts to better understand the molecu- lar and functional characteristics driving relapse and refractory disease may help improve this prognosis. This study has established a paediatric BL patient-derived xenograft (PDX) resource which captures and maintains tumour heterogeneity, may be used to better characterise tumours and identify cell populations responsible for therapy resistance.

Item Type: Article
Identification Number: https://doi.org/10.1111/bjh.17043
Date: 3 September 2020
Uncontrolled Keywords: Burkitt lymphoma, patient derived xenograft, relapse, B‐cell lymphoma, murine cancer models
Subjects: A100 Pre-clinical Medicine
Divisions: Faculty of Health, Education and Life Sciences > Centre for Social Care, Health and Related Research (C-SHARR) > Health Sciences
Depositing User: Jahangiri
Date Deposited: 04 Sep 2020 14:58
Last Modified: 04 Sep 2020 14:58
URI: http://www.open-access.bcu.ac.uk/id/eprint/9840

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