Molecular and Clinical Prognostic Biomarkers of COVID-19 Severity and Persistence

Papadopoulou, Gethsimani and Manoloudi, Eleni and Repousi, Nikolena and Skoura, Lemonia and Hurst, Tara and Karamitros, Timokratis (2022) Molecular and Clinical Prognostic Biomarkers of COVID-19 Severity and Persistence. Pathogens, 11 (3). p. 311. ISSN 2076-0817

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The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), poses several challenges to clinicians, due to its unpredictable clinical course. The identification of laboratory biomarkers, specific cellular, and molecular mediators of immune response could contribute to the prognosis and management of COVID-19 patients. Of utmost importance is also the detection of differentially expressed genes, which can serve as transcriptomic signatures, providing information valuable to stratify patients into groups, based on the severity of the disease. The role of biomarkers such as IL-6, procalcitonin, neutrophil–lymphocyte ratio, white blood cell counts, etc. has already been highlighted in recently published studies; however, there is a notable amount of new evidence that has not been summarized yet, especially regarding transcriptomic signatures. Hence, in this review, we assess the latest cellular and molecular data and determine the significance of abnormalities in potential biomarkers for COVID-19 severity and persistence. Furthermore, we applied Gene Ontology (GO) enrichment analysis using the genes reported as differentially expressed in the literature in order to investigate which biological pathways are significantly enriched. The analysis revealed a number of processes, such as inflammatory response, and monocyte and neutrophil chemotaxis, which occur as part of the complex immune response to SARS-CoV-2.

Item Type: Article
Identification Number:
27 February 2022Accepted
2 March 2022Published Online
Uncontrolled Keywords: SARS-CoV-2; COVID-19; pandemic; host immune response; prognostic biomarker; COVID-19 severity; COVID-19 persistence; transcriptomic signature; molecular biomarker; cellular biomarker
Subjects: CAH02 - subjects allied to medicine > CAH02-06 - allied health > CAH02-06-01 - health sciences (non-specific)
Divisions: Faculty of Health, Education and Life Sciences > School of Health Sciences
Depositing User: Tara Hurst
Date Deposited: 18 Mar 2022 16:48
Last Modified: 18 Mar 2022 16:48

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