Use of Honey in the Management of Chemotherapy-Associated Oral Mucositis in Paediatric Patients

Zhang, Luyang and Yin, Yan and Simons, Alison and Francisco, Ngiambudulu M and Wen, Feiqiu and Patil, Sandip (2022) Use of Honey in the Management of Chemotherapy-Associated Oral Mucositis in Paediatric Patients. Cancer Management and Research, 14. pp. 2773-2783. ISSN 1179-1322

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Background: Oral mucositis (OM) is a critical condition during chemotherapy in both adult and child cancer patients. Paediatric cancer patients have a higher prevalence of OM than adult cancer patients. Honey is a natural product that has been reported to have the best tissue healing properties. The present mini-review focused on the evaluation of the effectiveness of oral care with honey products in the treatment and prophylaxis of chemotherapy-induced OM in child patients.
Methods: A network of electronic English databases including CINAHL, CENTRAL, EMBASE, MEDLINE and PubMed, were used for primary search from April 2010 to April 2020. We have also considered data collected from, Web of Science and Google Scholar. PRISMA software was used to build collective data. Controlled trials were included in this review and were critically appraised by Down and Black. The narrative synthesis was performed.
Results: A total number of 346 data of children and adolescents with cancer were considered in this short review. All patients were from three randomized controlled trial articles and two were non-randomised controlled trial articles. Based on the evidence so far revealed, honey may show an effect in the treatment and prophylaxis of OM. The analysis of collected data revealed that the probability value P< 0.05. The honey enhanced recovery time and severity of OM were significantly compared with those without honey treatment receiving group of pediatric patients.
Conclusion: Honey not only has been shown to have the capability for healing injured tissues but it is also a more economical treatment, and it has fewer side effects compared to synthetic drugs. Honey or honey products can prevent chemotherapy-induced OM (CIOM) and be the best treatment to grade I, II and III CIOM. However, it is disappointing that studies involving children as patients were few, and limited data available so far.

Item Type: Article
Identification Number:
6 July 2022Accepted
19 September 2022Published Online
Uncontrolled Keywords: oral mucositis, honey, pediatric patients, chemotherapy
Subjects: CAH02 - subjects allied to medicine > CAH02-04 - nursing and midwifery > CAH02-04-01 - nursing (non-specific)
Divisions: Faculty of Health, Education and Life Sciences > School of Health Sciences
Depositing User: Gemma Tonks
Date Deposited: 26 Jul 2023 14:59
Last Modified: 26 Jul 2023 14:59

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