Antibiotic susceptibility of uropathogens: a 3-year retrospective study at Ho Teaching Hospital of Ghana

Deku, John Gameli and Aninagyei, Enoch and Kpodo, Comfort Enyonam and Bedzina, Israel and Kinanyok, Silas and Asafo-Adjei, Karikari and Mensah, Prosper and Duneeh, Richard Vikpebah and Sewornu, Rita and Duedu, Kwabena (2024) Antibiotic susceptibility of uropathogens: a 3-year retrospective study at Ho Teaching Hospital of Ghana. Discover Medicine, 1. ISSN 3004-8885

[thumbnail of s44337-024-00073-z.pdf]
Preview
Text
s44337-024-00073-z.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (669kB)

Abstract

Background
Urinary tract infection (UTI) remains one of the most treated infections in primary healthcare over the last two decades. The infection is treated with antibiotics. However, there have been reported cases of increasing antibiotic resistance globally, limiting the available antibiotics for the treatment of the infection. The study aimed to determine the frequency of bacterial urinary tract infections and their antibiotic resistance pattern in Ho Teaching Hospital of Ghana from 2019–2021.

Methodology
Data on urine culture and susceptibility testing and patient demographics from 2019–2021 were collected from the microbiology unit archives with a designed Microsoft Excel 2019 form and later exported to IBM SPSS (v26) for statistical analysis on the uropathogens and their antibiotic resistance pattern. P-value < 0.05 was considered statistically significant.

Results
Out of 4806 records, 1005 bacterial isolates were found, with a total prevalence of 20.91%. The most prevalent group of organisms was the Enterobacteriaceae, with E. coli 409 (40.70%) being the most frequent isolate. Of the 772 isolates subjected to amikacin, 48(6.22%) and 6(0.78%) of the Gram-negative and Gram-positive bacterial organisms showed resistance to the antibiotic respectively. 58.96% (148/251) and 3.59% (9/251) of Gram-negatives and Gram-positives were resistant to cotrimoxazole. Out of the 1005 bacterial isolates, 165(16.42%), 161(16.02%) and 2(0.20%) showed multidrug resistance (MDR), extensively-drug resistance (XDR), and pandrug resistance (PDR) respectively.

Conclusion
There was a high antibiotic-resistant pattern among the uropathogens reported in this current study, hence, the Standard Treatment Guidelines may need to be updated to reflect the high rates of antibiotic resistance exhibited by most prevalent isolates.

Item Type: Article
Identification Number: 10.1007/s44337-024-00073-z
Dates:
Date
Event
17 September 2024
Accepted
3 October 2024
Published Online
Uncontrolled Keywords: Urinary tract infections, antibiotics, resistance, Ho Teaching Hospital
Subjects: CAH03 - biological and sport sciences > CAH03-01 - biosciences > CAH03-01-01 - biosciences (non-specific)
Divisions: Faculty of Health, Education and Life Sciences > College of Life Sciences
Depositing User: Gemma Tonks
Date Deposited: 15 Oct 2024 13:52
Last Modified: 15 Oct 2024 13:52
URI: https://www.open-access.bcu.ac.uk/id/eprint/15903

Actions (login required)

View Item View Item

Research

In this section...