Effect of Mediterranean diet on body mass index and fatigue severity in patients with multiple sclerosis: A systematic review and meta-analysis of clinical trials

Moravejolahkami, Amir Reza and Shakibaei, Mehdi and Sharma, Manoj and Mohammadnezhad, Masoud and Devarakonda, Sri Lakshmi Sravani (2024) Effect of Mediterranean diet on body mass index and fatigue severity in patients with multiple sclerosis: A systematic review and meta-analysis of clinical trials. Heliyon, 10 (18). e37705. ISSN 2405-8440

Preview

Text 1-s2.0-S240584402413736X-main.pdf - Published Version Available under License Creative Commons Attribution. Download (920kB)

Abstract

Background
Recent studies imply that Mediterranean Diet (MeD) may play an important role in the management of Multiple Sclerosis (MS). This meta-analysis aimed to evaluate the effectiveness of MeD in addressing MS-related complications.
Methods
A thorough search was performed in MEDLINE (PubMed), Scopus, EMBASE, ScienceDirect, Google Scholar, Web of Science, and the Central Cochrane Library, covering trials published until September 2023. The quantitative data were synthesized using random effect models through STATA14.
Results
After analyzing 228 entries, we found five Randomized Controlled Trials (RCTs) with a total of 540 participants, who had an average disease duration of 8.5 years. The combined effect size revealed a decrease in Body Mass Index (BMI) (Weighted Mean Difference [WMD] = −0.88 kg/m2; 95 % Confidence Interval [CI] = −1.68, −0.08; P = 0.030). There was also a non-significant marginal improvement in fatigue severity (WMD = −8.29; 95 % CI = −16.74, 0.16; P = 0.054).
Conclusion
Adherence to MeD may improve BMI and fatigue severity in MS patients. Further RCTs are needed to confirm the current results.

Item Type:	Article
Identification Number:	10.1016/j.heliyon.2024.e37705
Dates:	Date Event 9 September 2024 Accepted 14 September 2024 Published Online
Uncontrolled Keywords:	Mediterranean diet, Multiple sclerosis, Fatigue, Meta‐analysis, Systematic review
Subjects:	CAH02 - subjects allied to medicine > CAH02-04 - nursing and midwifery > CAH02-04-01 - nursing (non-specific)
Divisions:	Faculty of Health, Education and Life Sciences > College of Nursing and Midwifery
Depositing User:	Gemma Tonks
Date Deposited:	12 Feb 2025 13:35
Last Modified:	12 Feb 2025 13:35
URI:	https://www.open-access.bcu.ac.uk/id/eprint/16153

Actions (login required)

View Item