Seizure prediction in pregnant women with epilepsy: An umbrella review of clinical practice guidelines and systematic reviews

Junaid, Fatima and Davies, Bethan and Tariq, Saba and Zamara, Javier and Moss, Ngawai and Black, Mairead and Wilson, Amie and Dyson, Judith and Weckesser, Annalise and Craig, John and Bromley, Rebecca and Thangaratinam, Shakila and Allotey, John (2025) Seizure prediction in pregnant women with epilepsy: An umbrella review of clinical practice guidelines and systematic reviews. European Journal of Obstetrics & Gynecology and Reproductive Biology, 308. pp. 241-250. ISSN 0301-2115

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Abstract

Objective
To identify risk factors for seizure in pregnant women, and in the general population with epilepsy.
Study design
Umbrella review of clinical practice guidelines and systematic reviews on risk factors or prediction models for seizure occurrence in pregnant women with epilepsy, adults with epilepsy, or all individuals with epilepsy. Guidelines or systematic reviews exclusively for children were excluded. We searched MEDLINE, Emcare, Embase, CINAHL, TRIP PRO, Epistemonikos, World Health Organisation, Guideline International Network, DANS, and grey literature (2000-2023) without language restrictions. Risk factors or predictors listed in the final guidelines or systematic reviews were collated and thematically analysed.
Results
From 3406 citations, we included 13 articles (ten guidelines, three systematic reviews) reporting 26 risk factors in pregnant women and the general adult population with epilepsy: eight factors in guidelines for pregnant women only; five in both pregnant women and general adult populations (four in both guidelines and systematic reviews, one in guidelines only); and 13 factors in the general adult population (four in both guidelines and systematic reviews, eight in guidelines, and one in a systematic review). Risk factors were categorised into five broad themes: seizure type; seizure control; anti-seizure medication; neurological; and epilepsy and medical history. Three risk factors for seizure ocurrence were cited in more than two guidelines or systematic reviews: seizure freedom (reduced risk), immediate initiation of anti-seizure medication after first seizure (reduced risk), and abnormal electroencephalogram (increased risk). Three risk factors were linked to a more than two-fold chance of seizures in pregnant women with epilepsy: tonic-clonic seizures in the last three months (RR 7.20, 95% CI 6.63-11.93), a history of non-tonic-clonic seizures (RR 2.11, 95% CI 1.88—2.62), and seizures in the pre-pregnancy year compared to no seizures (RR 3.51, 95% CI 3.13-3.94).
Conclusion
Multiple risk factors have been recommended for use in practice across different guidelines and reviews to identify those at increased risk of seizures in the adult population with epilepsy, and specifically in pregnant women with epilepsy. Further research is needed on the implementation of tools for predicting seizures to improve maternal and neonatal outcomes.

Item Type:	Article
Identification Number:	10.1016/j.ejogrb.2025.03.022
Dates:	Date Event 8 March 2025 Accepted 10 March 2025 Published Online
Uncontrolled Keywords:	Epilepsy, seizure risk, seizure prediction, risk factors
Subjects:	CAH02 - subjects allied to medicine > CAH02-06 - allied health > CAH02-06-01 - health sciences (non-specific)
Divisions:	Faculty of Health, Education and Life Sciences > Centre for Social Care, Health and Related Research (C-SHARR)
Depositing User:	Annalise Weckesser
Date Deposited:	17 Mar 2025 12:17
Last Modified:	17 Mar 2025 12:17
URI:	https://www.open-access.bcu.ac.uk/id/eprint/16237

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