Secondary antibody deficiencies in the modern era: emerging trends, diagnostic pitfalls, and advances in personalised management

Elkhalifa, Shuayb and Salvo, Fulvio and Elbashir, Haggar and Shafiq, Irfan and Isse, Saed and Abuzakouk, Mohamed and Gaber, Mohamed Medhat and Bhana, Rehan (2025) Secondary antibody deficiencies in the modern era: emerging trends, diagnostic pitfalls, and advances in personalised management. Frontiers in Immunology, 16. ISSN 1664-3224

Preview

Text fimmu-16-1635094.pdf - Published Version Available under License Creative Commons Attribution. Download (521kB)

Abstract

Secondary antibody deficiencies (SADs) are a significant but frequently under-recognised group of acquired immunodeficiencies. They may arise in various clinical settings, including haematological malignancies, immunosuppressive therapies, and protein-losing conditions. SADs are associated with an increased risk of recurrent and severe infections, hospitalisation, and impaired quality of life. Despite this, diagnostic and treatment pathways remain inconsistent across healthcare settings and regions. Recent advances in the use of structured clinical data, including electronic health records and systematic laboratory assessments, show promise in facilitating earlier recognition of SADs. These approaches support more timely treatment decisions and promote consistent standards of care. Achieving improved outcomes for individuals with SADs will require broader consensus on diagnostic criteria, treatment thresholds, and access to specialist immunology services.

Item Type:	Article
Identification Number:	10.3389/fimmu.2025.1635094
Dates:	Date Event 15 September 2025 Accepted 7 October 2025 Published Online
Uncontrolled Keywords:	secondary antibody deficiencies, hypogammaglobulinaemia, immunoglobulin replacement therapy, recurrent infections, haematological malignancy, immunosuppressive therapy, artificial intelligence, electronic health records
Subjects:	CAH01 - medicine and dentistry > CAH01-01 - medicine and dentistry > CAH01-01-02 - medicine (non-specific) CAH11 - computing > CAH11-01 - computing > CAH11-01-01 - computer science
Divisions:	Architecture, Built Environment, Computing and Engineering > Computer Science
Depositing User:	Gemma Tonks
Date Deposited:	18 Dec 2025 15:16
Last Modified:	18 Dec 2025 15:16
URI:	https://www.open-access.bcu.ac.uk/id/eprint/16781

Actions (login required)

View Item