Effect of anti-inflammatory diets based on complementary and alternative medicine in multiple sclerosis: a systematic review and meta-analysis of clinical trials

Moravejolahkami, Amir Reza and Nazari, Vida and Zare Hossein Abadi, Fatemeh and Mohammadnezhad, Masoud (2026) Effect of anti-inflammatory diets based on complementary and alternative medicine in multiple sclerosis: a systematic review and meta-analysis of clinical trials. Nutritional Neuroscience. pp. 1-16. ISSN 1028-415X

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Abstract

Background

The role of diet in modulating inflammation has garnered attention, particularly regarding anti-inflammatory dietary interventions rooted in complementary medicine. The present study examined the clinical manifestations through which anti-inflammatory diets may influence MS, providing insights for clinician researchers.

Methods

A thorough search was performed in Scopus, MEDLINE (PubMed), ScienceDirect, EMBASE, Google Scholar, Central Cochrane Library, and the Web of Science, covering trials published until December 2025. Random-effects models were used to analyze the quantitative data through STATA14.

Results

After analyzing 246 entries, we found 10 Randomized Controlled Trials (RCTs) with a total of 332 participants, who had an average disease duration of 8.7 years. The combined effect size revealed a decrease in fatigue severity (Weighted Mean Difference [WMD] = −7.10; 95% Confidence Interval [CI] = −13.61, −0.59; P = 0.032) and an increase in physical health score (WMD = 2.59; 95% Confidence Interval [CI] = 0.17, 5.00; P = 0.036).

Conclusion

Anti-inflammatory diets may improve MS clinical manifestations, especially fatigue and disability; therefore, more research is needed to confirm the present findings.

Item Type:	Article
Identification Number:	10.1080/1028415X.2026.2717197
Dates:	Date Event 4 August 2026 Accepted 18 August 2026 Published Online
Uncontrolled Keywords:	Multiple sclerosis, Anti-inflammatory diet, Complementary Therapies, Inflammation, Meta‐analysis, Systematic review
Subjects:	CAH02 - subjects allied to medicine > CAH02-04 - nursing and midwifery > CAH02-04-02 - adult nursing
Divisions:	Nursing and Midwifery > Adult Nursing
Depositing User:	Gemma Tonks
Date Deposited:	08 Sep 2026 10:16
Last Modified:	08 Sep 2026 10:18
URI:	https://www.open-access.bcu.ac.uk/id/eprint/17231

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