Cognitive Behavioral Therapy Lowers Elevated Functional Connectivity in Depressed Adolescents

Chattopadhyay, Shayanti and Tait, Roger and Simas, Tiago and van Nieuwenhuizen, Adrienne O. and Hagan, Cindy C. and Holt, Rosemary J. and Graham, Julia and Sahakian, Barbara J. and Wilkinson, Paul O. and Goodyer, Ian M. and Suckling, John (2017) Cognitive Behavioral Therapy Lowers Elevated Functional Connectivity in Depressed Adolescents. EBioMedicine, 17. pp. 216-222. ISSN 2352-3964

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Imaging studies have implicated altered functional connectivity in adults with major depressive disorder (MDD). Whether similar dysfunction is present in adolescent patients is unclear. The degree of resting-state functional connectivity (rsFC) may reflect abnormalities within emotional (‘hot’) and cognitive control (‘cold’) neural systems. Here, we investigate rsFC of these systems in adolescent patients and changes following cognitive behavioural therapy (CBT). Functional Magnetic Resonance Imaging (fMRI) was acquired from adolescent patients before CBT, and 24-weeks later following completed therapy. Similar data were obtained from control participants. Cross-sectional Cohort: From 82 patients and 34 controls at baseline, rsFC of the amygdala, anterior cingulate cortex (ACC), and pre-frontal cortex (PFC) was calculated for comparison. Longitudinal Cohort: From 17
patients and 30 controls with longitudinal data, treatment effects were tested on rsFC. Patients demonstrated significantly greater rsFC to left amygdala, bilateral supragenual ACC, but not with PFC. Treatment effects were observed in right insula connected to left supragenual ACC, with baseline case-control differences reduced. rsFC
changes were significantly correlated with changes in depression severity. Depressed adolescents exhibited
heightened connectivity in regions of ‘hot’ emotional processing, known to be associated with depression,
where treatment exposure exerted positive effects, without concomitant differences in areas of ‘cold’ cognition.

Item Type: Article
16 February 2017Published Online
13 February 2017Accepted
Uncontrolled Keywords: Depression Adolescence Resting-state Functional connectivity Fronto-limbic Cortical thickness
Subjects: CAH11 - computing > CAH11-01 - computing > CAH11-01-01 - computer science
Divisions: Faculty of Computing, Engineering and the Built Environment
Faculty of Computing, Engineering and the Built Environment > School of Computing and Digital Technology
Depositing User: Ian Mcdonald
Date Deposited: 06 Nov 2017 09:22
Last Modified: 22 Mar 2023 12:01

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