Effects of short-term temperature change in the innocuous range on histaminergic and non-histaminergic acute itch

Lewis, Z and George, D and Cowdell, Fiona and Holle, H (2019) Effects of short-term temperature change in the innocuous range on histaminergic and non-histaminergic acute itch. Acta Dermato-Venereologica, 99. pp. 188-195.

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While temperatures in the noxious range are well-known to inhibit acute itch, the impact of temperature in the innocuous temperature range is less well understood. We investigated the effect of alternating short-term temperature changes in the innocuous range on histamine and cowhage-induced acute itch, taking into account individual differences in baseline skin temperature and sensory thresholds. Results indicate that cooling the skin to the cold threshold causes a temporary increase in the intensity of histamine-induced itch, in line with previous findings. Skin warming increased cowhage-induced itch intensity. Potential mechanisms of this interaction between thermosensation and pruritoception could involve cold-sensitive channels such as TRPM8, TREK-1 or TRPC5 in the case of histamine. The rapid modulation of cowhage induced itch - but not histamine-induced itch - by transient skin warming could be related to the lower temperature threshold of pruriceptive polymodal C-fibres (cowhage) as compared to the higher temperature threshold of the mechanoinsensitive C-Fibres conveying histaminergic itch.

Item Type: Article
Identification Number: https://doi.org/10.2340/00015555-3077
17 October 2018Accepted
31 January 2019Published
Uncontrolled Keywords: Skin temperature, Histamine, Sensory Thresholds, Pruritus
Subjects: CAH02 - subjects allied to medicine > CAH02-04 - nursing and midwifery > CAH02-04-01 - nursing (non-specific)
Divisions: Faculty of Health, Education and Life Sciences > School of Nursing and Midwifery
Depositing User: Fiona Cowdell
Date Deposited: 22 Oct 2018 08:52
Last Modified: 03 Mar 2022 15:37
URI: https://www.open-access.bcu.ac.uk/id/eprint/6492

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