The psychological implications and health risks of cystic fibrosis pre- and post- CFTR modulator therapy

Keyte, Rebecca and Kauser, Sophia and Mantzios, Michail and Egan, Helen (2022) The psychological implications and health risks of cystic fibrosis pre- and post- CFTR modulator therapy. Chronic Illness. p. 174239532210990. ISSN 1742-3953

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Abstract

Objectives
Cystic Fibrosis (CF) care is entering a period of personalised medicine with the emergence of CF transmembrane conductance regulator (CFTR) modulator therapies. Anecdotally individuals are reporting life-changing effects of modulator therapies, proposing an important area of study.

Methods
Twenty adult participants (males: 8, age range: 22–51 years, average FEV1: 53.45%) were recruited via social media to participate in a semi-structured interview; 17 participants were currently taking Elexacaftor/Tezacaftor/Ivacaftor (Kaftrio).

Results
An appreciation of a “normal life” post-modulator therapy is paramount, with improvements in symptoms and quality-of-life bringing a more urgent imperative for the provision of effective support to encourage positive health and lifestyle choices.

Discussion
In this new era of CF care, there remains many challenges present for the CF community, with participants suggesting that proactive psychological support is required along with proactive awareness regarding health risk behaviours for the current and future CF generations.

Item Type: Article
Identification Number: https://doi.org/10.1177/17423953221099042
Dates:
DateEvent
13 April 2022Accepted
3 May 2022Published Online
Uncontrolled Keywords: Cystic fibrosis, CFTR modulator therapies, Kaftrio, Trikafta, qualitative methods
Subjects: CAH04 - psychology > CAH04-01 - psychology > CAH04-01-01 - psychology (non-specific)
Divisions: Faculty of Business, Law and Social Sciences > School of Social Sciences > Dept. Psychology
Depositing User: Rebecca Keyte
Date Deposited: 17 May 2022 09:02
Last Modified: 17 May 2022 09:25
URI: http://www.open-access.bcu.ac.uk/id/eprint/13229

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