Attentional deficits in Alzheimer’s: investigating the role of acetylcholine with computational modelling

Mavritsaki, Eirini and Bowman, Howard and Su, Li (2019) Attentional deficits in Alzheimer’s: investigating the role of acetylcholine with computational modelling. In: Multiscale Models of Brain Disorders. Springer, pp. 113-126. ISBN 9783030188306

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Abstract

Attention is a very important cognitive process that is employed for many actions in our everydaylife (e.g. watching television, reading a paper, washing our face, eatingand so on). It is therefore essential to investigate further the underlying mechanisms inneuro-degenerativeconditions, like Alzheimer’s disease, in which ourattentional abilities are reduced(Festa, Heindel, & Ott, 2010; Foster, Behrmann, & Stuss, 1999; Hao et al., 2005; Porter, Tales, et al., 2010; Redel et al., 2012; A. Tales et al., 2002a; Vallejo et al., 2016).Alzheimer’s disease is a condition that can take severalyears if not decades from the time it starts to the time the full symptoms are shown (Tijms & Visser, 2018).In those years of disease progression,there are a number of pathological processes that are taking place, however one of the starting point of the pathologyis believed to be the aggregation of βamyloids into plaques(Gordon et al., 2018; Tijms & Visser, 2018). Irrespective ofthe amount of research that has taken place,manyquestionsremain on how the disease unfolds and how to identify individual’s position in the disease’s trajectory(Gordon et al., 2018; Ryman et al., 2014).

Item Type:	Book Section
Dates:	Date Event 3 December 2018 Accepted 11 October 2019 Published
Uncontrolled Keywords:	Alzheimer's, attention, sSoTS, computational modelling, neurotransmitter
Subjects:	CAH04 - psychology > CAH04-01 - psychology > CAH04-01-01 - psychology (non-specific)
Divisions:	Faculty of Business, Law and Social Sciences > School of Social Sciences > Dept. Psychology
Depositing User:	Eirini Mavritsaki
Date Deposited:	05 Dec 2018 11:59
Last Modified:	03 Mar 2022 15:42
URI:	https://www.open-access.bcu.ac.uk/id/eprint/6691

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