TTN genotype is associated with fascicle length and marathon running performance

Stebbings, G K and Williams, A G and Herbert, Adam J. and Lockey, S J and Heffernan, S M and Erskine, R M and Morse, C I and Day, S H (2018) TTN genotype is associated with fascicle length and marathon running performance. Scandinavian journal of medicine & science in sports, 28 (2). pp. 400-406. ISSN 1600-0838

Stebbings et al. (2018) - TTN genotype is associated with fascicle length and marathon running performance.pdf

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Titin provides a molecular blueprint for muscle sarcomere assembly, and sarcomere length can vary according to titin isoform expression. If variations in sarcomere length influence muscle fascicle length, this may provide an advantage for running performance. Thus, the aim of this study was to investigate whether the titin (TTN) rs10497520 polymorphism was associated with muscle fascicle length in recreationally active men (RA; n=137) and marathon personal best time in male marathon runners (MR; n=141). Fascicle length of the vastus lateralis was assessed in vivo using B-mode ultrasonography at 50% of muscle length in RA. All participants provided either a whole blood, saliva or buccal cell sample, from which DNA was isolated and genotyped using real-time polymerase chain reaction. Vastus lateralis fascicle length was 10.4% longer in CC homozygotes, those carrying two copies of the C-allele, than CT heterozygotes (P=.003) in RA. In the absence of any TT homozygotes, reflective of the low T-allele frequency within Caucasian populations, it is unclear whether fascicle length for this group would have been smaller still. No differences in genotype frequency between the RA and MR groups were observed (P=.500), although within the MR group, the T-allele carriers demonstrated marathon personal best times 2 minutes 25 seconds faster than CC homozygotes (P=.020). These results suggest that the T-allele at rs10497520 in the TTN gene is associated with shorter skeletal muscle fascicle length and conveys an advantage for marathon running performance in habitually trained men.

Item Type: Article
February 2018Published
30 May 2017Accepted
Subjects: CAH03 - biological and sport sciences > CAH03-01 - biosciences > CAH03-01-07 - genetics
CAH03 - biological and sport sciences > CAH03-02 - sport and exercise sciences > CAH03-02-01 - sport and exercise sciences
CAH02 - subjects allied to medicine > CAH02-05 - medical sciences > CAH02-05-04 - anatomy, physiology and pathology
Divisions: Faculty of Health, Education and Life Sciences > Centre for Social Care, Health and Related Research (C-SHARR)
Depositing User: Adam Herbert
Date Deposited: 18 Mar 2019 08:33
Last Modified: 03 Mar 2022 17:15

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