Elevated ad libitum alcohol consumption following continuous theta burst stimulation to the left-dorsolateral prefrontal cortex is partially mediated by changes in craving

McNeill, Adam M. and Monk, Rebecca L. and Qureshi, Adam W. and Makris, Stergios and Cazzato, Valantina and Heim, Derek (2021) Elevated ad libitum alcohol consumption following continuous theta burst stimulation to the left-dorsolateral prefrontal cortex is partially mediated by changes in craving. Cognitive, Affective & Behavioral Neuroscience. ISSN 1531-135X

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Abstract

Previous research indicates that following alcohol intoxication, activity in prefrontal cortices is reduced, linking to changes in associated cognitive processes, such as inhibitory control, attentional bias (AB), and craving. While these changes have been implicated in alcohol consumption behaviour, it has yet to be fully illuminated how these frontal regions and cognitive processes interact to govern alcohol consumption behaviour. The current preregistered study applied continuous theta burst transcranial magnetic stimulation (cTBS) to examine directly these relationships while removing the wider pharmacological effects of alcohol. A mixed design was implemented, with cTBS stimulation to right and left dorsolateral prefrontal cortex (DLPFC), the medial orbital frontal cortex (mOFC) and Vertex, with measures of inhibitory control, AB, and craving taken both pre- and post-stimulation. Ad libitum consumption was measured using a bogus taste task. Results suggest that rDLPFC stimulation impaired inhibitory control but did not significantly increase ad libitum consumption. However, lDLPFC stimulation heightened craving and increased consumption, with findings indicating that changes in craving partially mediated the relationship between cTBS stimulation of prefrontal regions and ad libitum consumption. Medial OFC stimulation and AB findings were inconclusive. Overall, results implicate the left DLPFC in the regulation of craving, which appears to be a prepotent cognitive mechanism by which alcohol consumption is driven and maintained. [Abstract copyright: © 2021. The Author(s).]

Item Type:	Article
Additional Information:	** From PubMed via Jisc Publications Router ** History: accepted 28-07-2021.
Identification Number:	10.3758/s13415-021-00940-7
Dates:	Date Event 28 July 2021 Accepted 19 August 2021 Published
Uncontrolled Keywords:	Craving, AlcoholBinge drinking, TMS, Attentional bias, Inhibitory control
Subjects:	CAH04 - psychology > CAH04-01 - psychology > CAH04-01-01 - psychology (non-specific)
Divisions:	Faculty of Business, Law and Social Sciences > College of Psychology
SWORD Depositor:	JISC PubRouter
Depositing User:	JISC PubRouter
Date Deposited:	02 Sep 2021 08:12
Last Modified:	11 Jun 2024 13:03
URI:	https://www.open-access.bcu.ac.uk/id/eprint/12136

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