The Effect of Prebiotics and Oral Anti-Diabetic Agents on Gut Microbiome in Patients with Type 2 Diabetes: A Systematic Review and Network Meta-Analysis of Randomised Controlled Trials

Ojo, Omorogieva and Wang, Xiaohua and Ojo, Osarhumwese Osaretin and Brooke, Joanne and Jiang, Yiqing and Dong, Qingqing and Thompson, Trevor (2022) The Effect of Prebiotics and Oral Anti-Diabetic Agents on Gut Microbiome in Patients with Type 2 Diabetes: A Systematic Review and Network Meta-Analysis of Randomised Controlled Trials. Nutrients, 14 (23). ISSN 2072-6643

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Abstract

Background: Nutritional interventions such as the use of prebiotics can promote eubiosis of gut microbiome and maintain glucose homeostasis in patients with type 2 diabetes (T2D). However, it would appear that results of the effects of prebiotics on the community of microbes in the gut are not consistent.
Aim: To examine the effect of prebiotics and oral antidiabetic agents on gut microbiome in patients with T2D.
Methods: The PRISMA Extension Statement for Systematic Reviews and Network Meta-analyses was used to conduct this review. Searches were carried out in EMBASE, EBSCO-host databases, Google Scholar and the reference lists of articles for studies that are relevant to the research question, from database inception to 15 August 2022. The search strategy was based on PICOS framework. Network Meta-analysis which allows the estimation of relative treatment effects by combing both direct trial evidence (e.g., treatment A vs. treatment B) and indirect evidence was conducted. Furthermore, pairwise meta-analysis was also carried out to estimate effect sizes based on head-to-head comparisons of treatments and/or control conditions.
Results: Findings of the Network meta-analysis revealed that prebiotics significantly reduced HbA1c compared with control and the SMD was

Item Type:	Article
Identification Number:	10.3390/nu14235139
Dates:	Date Event 29 November 2022 Accepted 2 December 2022 Published Online
Uncontrolled Keywords:	prebiotics, oral anti-diabetic agents, gut microbiome, glycated haemoglobin, type 2 diabetes, Network meta-analysis, meta-analysis
Subjects:	CAH02 - subjects allied to medicine > CAH02-04 - nursing and midwifery > CAH02-04-01 - nursing (non-specific)
Divisions:	Faculty of Health, Education and Life Sciences > Centre for Social Care, Health and Related Research (C-SHARR)
Depositing User:	Joanne Brooke
Date Deposited:	03 Jan 2023 11:35
Last Modified:	03 Jan 2023 11:35
URI:	https://www.open-access.bcu.ac.uk/id/eprint/14040

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