Lignin derived nanoparticle intercalation on nitrogen-doped graphene quantum dots for electrochemical sensing of cardiac biomarker

Vasudevan, Mugashini and Remesh, Sathaniswarman and Perumal, Veeradasan and Bothi Raja, Pandian and Mohamad Ibrahim, Mohamad Nasir and CB Gopinath, Subash and Lee, Hooi-Ling and Karuppanan, Saravanan and Ovinis, Mark and Arumugam, Natarajan and Suresh Kumar, Raju (2023) Lignin derived nanoparticle intercalation on nitrogen-doped graphene quantum dots for electrochemical sensing of cardiac biomarker. Microchemical Journal, 195. ISSN 0026-265X

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Abstract

Lignin-scribed graphene (LSG) conjugated with nitrogen-doped graphene quantum dots (N-GQDs) and lignin derived silver nanoparticles (Ag NPs) was developed through a hydrothermal process for the electrochemical sensing of Troponin I, a cardiac biomarker for Acute Myocardial Infarction (AMI). A nanocomposite with optimal conduction mechanism was developed by varying the N-GQDs doped amount intercalated on the surface of LSG. The nanocomposite was characterised by morphological, physical, and structural examinations. The Ag NPs and N-GQDs were found uniformly distributed on the LSG surface, with selective capture of the biotinylated aptamer probe on the bio-electrode indicative of the specific interaction with Troponin I, resulting in an increment in the charge transfer resistance following hybridisation analysis. The detection limit, as determined through impedance spectroscopy, was 1 fM or 30 fg/mL, with high levels of linearity, selectivity, repeatability, and stability of the sensor. This nanocomposite opens a new avenue for array-based medical diagnostics.

Item Type:	Article
Identification Number:	10.1016/j.microc.2023.109405
Dates:	Date Event 20 September 2023 Accepted 23 September 2023 Published Online
Uncontrolled Keywords:	lignin-derived graphene, nitrogen-doped graphene quantum dots, silver nanoparticles, troponin I, biosensor
Subjects:	CAH10 - engineering and technology > CAH10-01 - engineering > CAH10-01-06 - bioengineering, medical and biomedical engineering
Divisions:	Faculty of Computing, Engineering and the Built Environment > College of Engineering
Depositing User:	Mark Ovinis
Date Deposited:	11 Dec 2023 12:42
Last Modified:	20 Jun 2024 11:50
URI:	https://www.open-access.bcu.ac.uk/id/eprint/15037

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