Adverse Effects of a Single Dose of Gentamicin in Adults: A Systematic Review.

Hayward, R S and Harding, J and Molloy, R and Land, L and Longcroft-Neal, K and Moore, D and Ross, J. D. C. (2017) Adverse Effects of a Single Dose of Gentamicin in Adults: A Systematic Review. British journal of clinical pharmacology. ISSN 1365-2125

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Abstract

AIM

Systematically review the frequency and type of adverse events associated with a single dose of intravenous or intramuscular gentamicin in adults, for any indication, in studies where a comparator was available.

METHODS

A review protocol was developed and registered (PROSPERO: CRD42013003229). Studies were eligible for review if they; recruited participants ≥16 years old, used gentamicin intramuscularly or intravenously as a single one-off dose, compared gentamicin to another medication or placebo, and if adverse events were monitored. MEDLINE, EMBASE, Cochrane Library, trial registries, conference proceedings and other relevant databases were searched up to November 2016. Risk of bias was assessed on all included studies.

RESULTS

15,522 records were identified. After removal of duplicates, screening of title/abstracts for relevance and independent selection of full texts by two reviewers, 36 studies were included. 24,107 received a single one-off dose of gentamicin (doses ranged from 1mg/kg - 480mg per dose). Acute kidney injury was described in 2520 participants receiving gentamicin. The large majority of cases were reversible. There were no cases of ototoxicity reported in patients receiving gentamicin. A meta-analysis was not performed due to study heterogeneity.

CONCLUSIONS

A significant number of patients saw a transient rise in creatinine after a single dose of gentamicin at doses up to 480mg. Persistent renal impairment and other adverse events were relatively rare.

Item Type:	Article
Identification Number:	10.1111/bcp.13439
Dates:	Date Event 3 November 2017 Published Online 9 September 2017 Accepted
Subjects:	CAH02 - subjects allied to medicine > CAH02-05 - medical sciences > CAH02-05-04 - anatomy, physiology and pathology CAH02 - subjects allied to medicine > CAH02-02 - pharmacology, toxicology and pharmacy > CAH02-02-01 - pharmacology CAH01 - medicine and dentistry > CAH01-01 - medicine and dentistry > CAH01-01-01 - medical sciences (non-specific)
Divisions:	Faculty of Health, Education and Life Sciences > Centre for Social Care, Health and Related Research (C-SHARR)
Depositing User:	Lucy Land
Date Deposited:	10 Oct 2017 08:07
Last Modified:	03 Mar 2022 17:15
URI:	https://www.open-access.bcu.ac.uk/id/eprint/5212

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